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F57A8.7 MFS domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186432, updated on 2-Nov-2024

Summary

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Official Symbol
F57A8.7
Official Full Name
MFS domain-containing protein
Primary source
WormBase:WBGene00010182
Locus tag
CELE_F57A8.7
See related
AllianceGenome:WB:WBGene00010182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F57A8.7 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (10075741..10077906)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nuclear receptor domain-containing protein Neighboring gene protein of unknown function DX domain-containing protein Neighboring gene TMhelix containing protein Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-12;Nuclear receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MFS domain-containing protein
NP_505586.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10075741..10077906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073185.2 → NP_505586.1  MFS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBJ1
    Conserved Domains (2) summary
    cd06174
    Location:11 → 437
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:25 → 421
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
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