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daam-1 FH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186392, updated on 4-Jan-2025

Summary

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Official Symbol
daam-1
Official Full Name
FH2 domain-containing protein
Primary source
WormBase:WBGene00018976
Locus tag
CELE_F56E10.2
See related
AllianceGenome:WB:WBGene00018976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in positive regulation of actin filament polymerization. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to several human genes including DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See daam-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (64530..83832, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The canonical eIF4E isoform of C. elegans regulates growth, embryogenesis, and germline sex-determination. Mangio RS, et al. Biol Open, 2015 May 15. PMID 25979704, Free PMC Article
  2. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Mi-Mi L, et al. J Cell Biol, 2012 Jul 9. PMID 22753896, Free PMC Article
  3. FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner. Sundaramurthy S, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 33103378, Free PMC Article
  4. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. King RS, et al. Dev Biol, 2009 Apr 15. PMID 19298786, Free PMC Article
  5. Wnt signaling establishes the microtubule polarity in neurons through regulation of Kinesin-13. Puri D, et al. J Cell Biol, 2021 Sep 6. PMID 34137792, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FH2 domain-containing protein
NP_001300119.1
  • Partially confirmed by transcript evidence
NP_001300120.1
  • Confirmed by transcript evidence
NP_503132.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    64530..83832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070731.6 → NP_503132.3  FH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503132.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6VPA1
    Conserved Domains (3) summary
    smart00498
    Location:524 → 973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:216 → 408
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:39 → 212
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001313190.3 → NP_001300119.1  FH2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXY1
    Conserved Domains (2) summary
    smart00498
    Location:355 → 804
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:47 → 239
    Drf_FH3; Diaphanous FH3 Domain

  3. NM_001313191.3 → NP_001300120.1  FH2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASL6
    Conserved Domains (1) summary
    smart00498
    Location:1 → 361
    FH2; Formin Homology 2 Domain
Nucleotide Protein
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