cbs-2 Putative cystathionine beta-synthase cbs-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cbs-2
Official Full Name: Putative cystathionine beta-synthase cbs-2
Primary source: WormBase:WBGene00018783
Locus tag: CELE_F54A3.4
See related: AllianceGenome:WB:WBGene00018783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cystathionine beta-synthase activity. Predicted to be involved in cysteine biosynthetic process from serine. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cbs-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (2220396..2223567, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization of Caenorhabditis elegans cbs-2 gene during meiosis.
Title: Functional characterization of Caenorhabditis elegans cbs-2 gene during meiosis.
present study provides the first insight into the metabolism of sulfur amino acids and hydrogen sulfide in C. elegans and shows that nematode CBSs (cystathionine beta-synthases) possess a structural feature that is unique among CBS proteins
Title: Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54A3_30.a (e-PCR)
- UniSTS:324237

F54A3_30.b (e-PCR)
- UniSTS:322556

F54A3_30.c (e-PCR)
- UniSTS:322557

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cystathionine beta-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative cystathionine beta-synthase cbs-2

NP_494215.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

2220396..2223567 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061814.4 → NP_494215.2 Putative cystathionine beta-synthase cbs-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494215.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N4K2

Conserved Domains (2) summary

COG0031
Location:21 → 290

CysK; Cysteine synthase [Amino acid transport and metabolism]

TIGR01137
Location:336 → 662

cysta_beta; cystathionine beta-synthase