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F54A3.2 TOG domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186196, updated on 4-Jan-2025

Summary

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Official Symbol
F54A3.2
Official Full Name
TOG domain-containing protein
Primary source
WormBase:WBGene00018781
Locus tag
CELE_F54A3.2
See related
AllianceGenome:WB:WBGene00018781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule binding activity and microtubule plus end polymerase. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in intracellular membraneless organelle and supramolecular complex. Predicted to be active in centrosome; kinetochore; and spindle pole. Predicted to colocalize with microtubule plus-end. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F54A3.2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (2243642..2254368)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Periphilin-1-like;Trithorax group protein osa Neighboring gene ncRNA Neighboring gene T-complex protein 1 subunit gamma Neighboring gene ncRNA Neighboring gene WSN domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus end polymerase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus end polymerase IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membraneless organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in supramolecular complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TOG domain-containing protein
NP_494219.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2243642..2254368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061818.6 → NP_494219.4  TOG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494219.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4J7
    Conserved Domains (2) summary
    pfam15292
    Location:387 → 489
    Treslin_N; Treslin N-terminus
    sd00044
    Location:103 → 132
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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