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klf-2 Kruppel-like factor 2 [ Caenorhabditis elegans ]

Gene ID: 186179, updated on 2-Nov-2024

Summary

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Official Symbol
klf-2
Official Full Name
Kruppel-like factor 2
Primary source
WormBase:WBGene00009998
Locus tag
CELE_F53F8.1
See related
AllianceGenome:WB:WBGene00009998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of lipid metabolic process. Predicted to be located in nucleus. Is expressed in intestine. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See klf-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (20685683..20688830)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Cys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Krüppel-like family of transcription factors: an emerging new frontier in fat biology. Brey CW, et al. Int J Biol Sci, 2009 Oct 1. PMID 19841733, Free PMC Article
  2. Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage. Ling J, et al. Nutr Metab (Lond), 2017. PMID 28261316, Free PMC Article
  3. KLF regulation of insulin pathway genes. Wang H, et al. 3 Biotech, 2023 Mar. PMID 36816753, Free PMC Article
  4. Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant. Defoort J, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29873777, Free PMC Article
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kruppel-like factor 2
NP_507995.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20685683..20688830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075594.4 → NP_507995.2  Kruppel-like factor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507995.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62259
    Conserved Domains (1) summary
    sd00017
    Location:205 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62259.2

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