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sir-2.3 NAD-dependent protein deacylase sir-2.3 [ Caenorhabditis elegans ]

Gene ID: 185876, updated on 14-Nov-2024

Summary

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Official Symbol
sir-2.3
Official Full Name
NAD-dependent protein deacylase sir-2.3
Primary source
WormBase:WBGene00004802
Locus tag
CELE_F46G10.3
See related
AllianceGenome:WB:WBGene00004802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Located in mitochondrion. Is expressed in body wall musculature; head; pharynx; and somatic gonad. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sir-2.3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (13332014..13333846)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SEFIR domain-containing protein Neighboring gene NAD-dependent protein deacylase sir-2.2 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene SSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites. Zhang B, et al. Nat Chem Biol, 2024 Jul. PMID 38167917
  2. Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans. Sangaletti R, et al. PLoS Genet, 2017 Aug. PMID 28820880, Free PMC Article
  3. C. elegans sirtuins. Viswanathan M, et al. Methods Mol Biol, 2013. PMID 24014398
  4. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Wirth M, et al. Mitochondrion, 2013 Nov. PMID 23438705, Free PMC Article
  5. Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway. Li N, et al. Front Pharmacol, 2021. PMID 33935768, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD-dependent protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD-dependent protein deacylase sir-2.3
NP_510220.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13332014..13333846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077819.4 → NP_510220.1  NAD-dependent protein deacylase sir-2.3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20481
    Conserved Domains (1) summary
    cd01409
    Location:20 → 284
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20481.1

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