U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rme-4 UDENN domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185870, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
rme-4
Official Full Name
UDENN domain-containing protein
Primary source
WormBase:WBGene00004375
Locus tag
CELE_F46F6.1
See related
AllianceGenome:WB:WBGene00004375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Involved in endocytic recycling. Located in clathrin-coated pit. Is expressed widely. Orthologous to human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rme-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (10373232..10377769, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DM10 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Intraflagellar transport protein 46 homolog Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death. Kutscher LM, et al. Dev Cell, 2018 Oct 22. PMID 30220571, Free PMC Article
  2. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. Haley R, et al. PLoS Genet, 2018 Aug. PMID 30138370, Free PMC Article
  3. Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. Sato M, et al. EMBO J, 2008 Apr 23. PMID 18354496, Free PMC Article
  4. Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans. Plagens RN, et al. BMC Biol, 2021 Apr 15. PMID 33858388, Free PMC Article
  5. Temporally regulated cell migration is sensitive to variation in body size. Dubois C, et al. Development, 2021 Mar 5. PMID 33593818, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UDENN domain-containing protein
NP_001359519.1
  • Confirmed by transcript evidence
NP_509739.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10373232..10377769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373469.3 → NP_001359519.1  UDENN domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K7A5
    Conserved Domains (3) summary
    smart00801
    Location:315 → 383
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 282
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:12 → 86
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_077338.6 → NP_509739.1  UDENN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECW9
    Conserved Domains (3) summary
    smart00801
    Location:315 → 383
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:91 → 282
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:12 → 86
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools