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msra-1 peptide-methionine (S)-S-oxide reductase [ Caenorhabditis elegans ]

Gene ID: 185709, updated on 9-Dec-2024

Summary

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Official Symbol
msra-1
Official Full Name
peptide-methionine (S)-S-oxide reductase
Primary source
WormBase:WBGene00018393
Locus tag
CELE_F43E2.5
See related
AllianceGenome:WB:WBGene00018393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestine; and neurons. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See msra-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (7363220..7364040, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D Neighboring gene ABC-type antigen peptide transporter Neighboring gene Protein inscuteable homologue C-terminal domain-containing protein Neighboring gene Ovule protein Neighboring gene Peptidylprolyl isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans. Lee BC, et al. Arch Biochem Biophys, 2005 Feb 15. PMID 15639227
  2. Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. Minniti AN, et al. Aging Cell, 2019 Feb. PMID 30456853, Free PMC Article
  3. The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo. Minniti AN, et al. Antioxid Redox Signal, 2015 Jan 1. PMID 24988428, Free PMC Article
  4. Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Minniti AN, et al. Aging Cell, 2009 Dec. PMID 19747232
  5. Circadian stress tolerance in adult Caenorhabditis elegans. Simonetta SH, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2008 Sep. PMID 18648821

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans [MsrA]
    Title: Cloning and characterization of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans.
  2. found that the msra-1 gene is expressed in most tissues, particularly in the intestine and the nervous system.
    Title: Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-methionine-(S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (S)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptide-methionine (S)-S-oxide reductase
NP_495540.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7363220..7364040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063139.10 → NP_495540.1  peptide-methionine (S)-S-oxide reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02089
    Conserved Domains (1) summary
    pfam01625
    Location:6 → 134
    PMSR; Peptide methionine sulfoxide reductase
Nucleotide Protein
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