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ccnk-1 Cyclin-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185704, updated on 4-Jan-2025

Summary

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Official Symbol
ccnk-1
Official Full Name
Cyclin-like domain-containing protein
Primary source
WormBase:WBGene00009650
Locus tag
CELE_F43D2.1
See related
AllianceGenome:WB:WBGene00009650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in nematode larval development. Located in nucleus. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ccnk-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (14612548..14613706)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene PEST proteolytic signal-containing nuclear protein;Shugoshin_C domain-containing protein;Uncharacterized protein Neighboring gene DZF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Bowman EA, et al. Development, 2013 Sep. PMID 23903194, Free PMC Article
  2. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  3. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cyclin-like domain-containing protein
NP_506615.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14612548..14613706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074214.5 → NP_506615.2  Cyclin-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506615.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17869
    Conserved Domains (1) summary
    COG5333
    Location:12 → 250
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
Nucleotide Protein
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