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alh-11 4-trimethylaminobutyraldehyde dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 185679, updated on 9-Dec-2024

Summary

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Official Symbol
alh-11
Official Full Name
4-trimethylaminobutyraldehyde dehydrogenase
Primary source
WormBase:WBGene00000117
Locus tag
CELE_F42G9.5
See related
AllianceGenome:WB:WBGene00000117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4-trimethylammoniobutyraldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Is expressed in neurons. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See alh-11 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (774321..778154, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Microtubule-associated protein Neighboring gene Putative protein-tyrosine sulfotransferase Neighboring gene Peptidyl-prolyl cis-trans isomerase 6 Neighboring gene sn-1-specific diacylglycerol lipase Neighboring gene Protein phosphatase ppm-1.G Neighboring gene Synaptotagmin 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states. Hardege I, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36413500, Free PMC Article
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-trimethylaminobutyraldehyde dehydrogenase
NP_001379574.1
  • Confirmed by transcript evidence
NP_001379575.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    774321..778154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393264.1 → NP_001379574.1  4-trimethylaminobutyraldehyde dehydrogenase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20352
    Conserved Domains (2) summary
    cd07090
    Location:225 → 681
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
    cl21534
    Location:30 → 131
    NLPC_P60; NlpC/P60 family

  2. NM_001393265.1 → NP_001379575.1  4-trimethylaminobutyraldehyde dehydrogenase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MNS6
    Conserved Domains (1) summary
    cd07090
    Location:41 → 497
    ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
Nucleotide Protein
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