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F42A6.6 Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185650, updated on 4-Jan-2025

Summary

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Official Symbol
F42A6.6
Official Full Name
Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein
Primary source
WormBase:WBGene00018328
Locus tag
CELE_F42A6.6
See related
AllianceGenome:WB:WBGene00018328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F42A6.6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (3334042..3336873, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BRCT domain-containing protein Neighboring gene ncRNA Neighboring gene Heterogeneous nuclear ribonucleoprotein A1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein
NP_001263742.1
  • Confirmed by transcript evidence
NP_001263743.1
  • Confirmed by transcript evidence
NP_001263744.1
  • Confirmed by transcript evidence
NP_001294457.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3334042..3336873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276815.3 → NP_001263744.1  Hikeshi-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ERU5
    Conserved Domains (1) summary
    pfam05603
    Location:5 → 213
    DUF775; Protein of unknown function (DUF775)

  2. NM_001276813.3 → NP_001263742.1  Hikeshi-like N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E808
    Conserved Domains (1) summary
    pfam05603
    Location:5 → 150
    DUF775; Protein of unknown function (DUF775)

  3. NM_001307528.4 → NP_001294457.1  Hikeshi-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBW7
    Conserved Domains (1) summary
    pfam05603
    Location:5 → 197
    DUF775; Protein of unknown function (DUF775)

  4. NM_001276814.4 → NP_001263743.1  Hikeshi-like N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263743.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FDZ3
    Conserved Domains (1) summary
    pfam05603
    Location:5 → 166
    DUF775; Protein of unknown function (DUF775)
Nucleotide Protein
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