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fis-1 FIS1-related protein fis-1 [ Caenorhabditis elegans ]

Gene ID: 185630, updated on 4-Jan-2025

Summary

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Official Symbol
fis-1
Official Full Name
FIS1-related protein fis-1
Primary source
WormBase:WBGene00001424
Locus tag
CELE_F41G3.4
See related
AllianceGenome:WB:WBGene00001424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid binding activity and molecular adaptor activity. Predicted to be involved in mitochondrial fission and peroxisome fission. Located in mitochondrial outer membrane. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fis-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (6755174..6755965)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene FH2 domain-containing protein Neighboring gene Agrin Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans. Bess AS, et al. Worm, 2013 Jan 1. PMID 24058863, Free PMC Article
  2. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Head BP, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248201, Free PMC Article
  3. Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation. Civelek M, et al. Mol Cell Biochem, 2019 Feb. PMID 30094600
  4. Loss of intermediate filament IFB-1 reduces mobility, density, and physiological function of mitochondria in Caenorhabditis elegans sensory neurons. Barmaver SN, et al. Traffic, 2022 May. PMID 35261124
  5. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FIS1-related protein fis-1
NP_495381.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6755174..6755965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062980.5 → NP_495381.1  FIS1-related protein fis-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495381.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20291
    Conserved Domains (1) summary
    cd12212
    Location:3 → 116
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20291.1

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