nhr-181 Nuclear Hormone Receptor family [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-181
Official Full Name: Nuclear Hormone Receptor family
Primary source: WormBase:WBGene00018189
Locus tag: CELE_F38H12.3
See related: AllianceGenome:WB:WBGene00018189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhr-181 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (4095040..4100541)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F38H12.3 (e-PCR)
- UniSTS:322116

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear Hormone Receptor family

NP_001317817.1

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NP_504139.1

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4095040..4100541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071738.2 → NP_504139.1 Nuclear Hormone Receptor family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504139.1

Status: REVIEWED

UniProtKB/TrEMBL

O16346

Conserved Domains (2) summary

cd06960
Location:33 → 107

NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

smart00430
Location:203 → 376

HOLI; Ligand binding domain of hormone receptors
NM_001330828.1 → NP_001317817.1 Nuclear Hormone Receptor family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168H5K4