F35H10.5 Centromere protein X [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F35H10.5
Official Full Name: Centromere protein X
Primary source: WormBase:WBGene00018070
Locus tag: CELE_F35H10.5
See related: AllianceGenome:WB:WBGene00018070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to be involved in replication fork processing and resolution of meiotic recombination intermediates. Predicted to be located in nucleus. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Orthologous to human CENPX (centromere protein X). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F35H10.5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (8300768..8301165)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35H10.7 (e-PCR)
- UniSTS:310143

F35H10.6 (e-PCR)
- UniSTS:320721

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in kinetochore assembly	IEA Inferred from Electronic Annotation more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FANCM-MHF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fanconi anaemia nuclear complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Centromere protein X

NP_501398.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8300768..8301165

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068997.4 → NP_501398.1 Centromere protein X [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501398.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20071

Conserved Domains (1) summary

pfam09415
Location:7 → 76

CENP-X; CENP-S associating Centromere protein X