U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

col-99 Cuticle collagen 99;Putative cuticle collagen 99 [ Caenorhabditis elegans ]

Gene ID: 185112, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
col-99
Official Full Name
Cuticle collagen 99;Putative cuticle collagen 99
Primary source
WormBase:WBGene00000674
Locus tag
CELE_F29C4.8
See related
AllianceGenome:WB:WBGene00000674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in axon guidance. Located in extracellular space; neuromuscular junction; and plasma membrane. Part of collagen trimer. Is expressed in anal depressor muscle; body wall musculature; hypodermis; neurons; and retrovesicular ganglion. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 5. Orthologous to human COL23A1 (collagen type XXIII alpha 1 chain) and COL25A1 (collagen type XXV alpha 1 chain). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See col-99 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
19
Sequence:
Chromosome: IV; NC_003282.8 (137974..147919, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Cell surface receptor daf-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans. Tu H, et al. BMC Evol Biol, 2015 Dec 14. PMID 26667623, Free PMC Article
  2. Isolation of mutations with dumpy-like phenotypes and of collagen genes in the nematode Pristionchus pacificus. Kenning C, et al. Genesis, 2004 Nov. PMID 15493014
  3. Transmembrane Collagens in Neuromuscular Development and Disorders. Wakabayashi T. Front Mol Neurosci, 2020. PMID 33536873, Free PMC Article
  4. The transmembrane collagen COL-99 guides longitudinally extending axons in C. elegans. Taylor J, et al. Mol Cell Neurosci, 2018 Jun. PMID 29550247
  5. Multiple Pathways Act Together To Establish Asymmetry of the Ventral Nerve Cord in Caenorhabditis elegans. Taylor J, et al. Genetics, 2019 Apr. PMID 30792268, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring tensile strength IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of collagen trimer IDA
Inferred from Direct Assay
more info
 PubMed 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
part_of collagen trimer NAS
Non-traceable Author Statement
more info
 PubMed 
part_of collagen type IV trimer IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Cuticle collagen 99;Putative cuticle collagen 99
NP_001122775.2
  • Confirmed by transcript evidence
NP_001294561.1
  • Confirmed by transcript evidence
NP_001294562.1
  • Confirmed by transcript evidence
NP_001294563.1
  • Confirmed by transcript evidence
NP_001309601.1
  • Confirmed by transcript evidence
NP_001309602.1
  • Confirmed by transcript evidence
NP_001309603.1
  • Confirmed by transcript evidence
NP_001309604.1
  • Confirmed by transcript evidence
NP_001309605.1
  • Confirmed by transcript evidence
NP_001309606.1
  • Confirmed by transcript evidence
NP_001309607.1
  • Confirmed by transcript evidence
NP_001309608.1
  • Confirmed by transcript evidence
NP_001309609.1
  • Confirmed by transcript evidence
NP_001309610.1
  • Confirmed by transcript evidence
NP_001309611.1
  • Confirmed by transcript evidence
NP_001309612.1
  • Confirmed by transcript evidence
NP_499869.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    137974..147919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067468.7 → NP_499869.3  Putative cuticle collagen 99 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499869.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76368
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  2. NM_001307634.4 → NP_001294563.1  Cuticle collagen 99 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294563.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRZ7
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  3. NM_001322775.2 → NP_001309601.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0F6YQF6
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  4. NM_001322764.3 → NP_001309612.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBK4
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  5. NM_001322765.3 → NP_001309608.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MAZ6
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  6. NM_001322766.3 → NP_001309610.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCG3
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  7. NM_001322767.3 → NP_001309606.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBL6
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  8. NM_001322768.3 → NP_001309611.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD72
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  9. NM_001322769.3 → NP_001309607.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB32
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  10. NM_001322770.3 → NP_001309609.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBJ3
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  11. NM_001322771.3 → NP_001309605.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCY1
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  12. NM_001322772.3 → NP_001309604.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCS7
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  13. NM_001322773.3 → NP_001309602.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBJ4
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  14. NM_001322774.3 → NP_001309603.1  Cuticle collagen 99 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBQ9
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  15. NM_001307632.3 → NP_001294561.1  Cuticle collagen 99 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PC95
    Conserved Domains (1) summary
    pfam01391
    Location:350 → 389
    Collagen; Collagen triple helix repeat (20 copies)

  16. NM_001307633.3 → NP_001294562.1  Cuticle collagen 99 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294562.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMN6
    Conserved Domains (1) summary
    pfam01391
    Location:362 → 401
    Collagen; Collagen triple helix repeat (20 copies)

  17. NM_001129303.4 → NP_001122775.2  Putative cuticle collagen 99 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122775.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WIS7, O76368
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76368.4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous