U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

selt-1.2 Thioredoxin reductase-like selenoprotein T homolog selt-1.2 [ Caenorhabditis elegans ]

Gene ID: 185097, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
selt-1.2
Official Full Name
Thioredoxin reductase-like selenoprotein T homolog selt-1.2
Primary source
WormBase:WBGene00009238
Locus tag
CELE_F28H7.4
See related
AllianceGenome:WB:WBGene00009238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Predicted to be active in endoplasmic reticulum membrane. Is expressed in AWBL and AWBR. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See selt-1.2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (10746496..10747363, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein wdr-5.3 Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class J Neighboring gene Serpentine Receptor, class J Neighboring gene DeHydrogenases, Short chain Neighboring gene Fungal lipase-like domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. Romanelli-Cedrez L, et al. Free Radic Biol Med, 2017 Jul. PMID 28347729
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans
    Title: Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Thioredoxin reductase-like selenoprotein T homolog selt-1.2
NP_505741.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10746496..10747363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073340.3 → NP_505741.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505741.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19892
    Conserved Domains (1) summary
    cl01407
    Location:72 → 209
    Rdx; Rdx family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19892.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools