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ntr-2 Nematocin receptor 2 [ Caenorhabditis elegans ]

Gene ID: 184471, updated on 4-Jan-2025

Summary

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Official Symbol
ntr-2
Official Full Name
Nematocin receptor 2
Primary source
WormBase:WBGene00008808
Locus tag
CELE_F14F4.1
See related
AllianceGenome:WB:WBGene00008808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in RMEV; ganglia; intestine; and oblique male muscle. Human ortholog(s) of this gene implicated in autism spectrum disorder; hypertension; mood disorder (multiple); nephrogenic diabetes insipidus (multiple); and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to several human genes including AVPR1A (arginine vasopressin receptor 1A); AVPR1B (arginine vasopressin receptor 1B); and AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ntr-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (14924974..14928954, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Multidrug resistance-associated protein 5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An oxytocin-dependent social interaction between larvae and adult C. elegans. Scott E, et al. Sci Rep, 2017 Aug 31. PMID 28860630, Free PMC Article
  2. The long and the short of it - a perspective on peptidergic regulation of circuits and behaviour. Jékely G, et al. J Exp Biol, 2018 Feb 8. PMID 29439060
  3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in behavior IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nematocin receptor 2
NP_510477.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14924974..14928954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078076.4 → NP_510477.1  Nematocin receptor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62169
    Conserved Domains (1) summary
    pfam00001
    Location:37 → 323
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62169.1

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