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gst-44 Glutathione S-transferase omega [ Caenorhabditis elegans ]

Gene ID: 184405, updated on 9-Dec-2024

Summary

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Official Symbol
gst-44
Official Full Name
Glutathione S-transferase omega
Primary source
WormBase:WBGene00001792
Locus tag
CELE_F13A7.10
See related
AllianceGenome:WB:WBGene00001792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in response to reactive oxygen species. Predicted to be active in cytoplasm. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gst-44 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (16390891..16392490)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-63 Neighboring gene Ubiquitinyl hydrolase 1 Neighboring gene Methyltransferase FkbM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860
  2. The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. Lüersen K, et al. PLoS One, 2013. PMID 23593298, Free PMC Article
  3. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glutathione S-transferase omega
NP_507142.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16390891..16392490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074741.4 → NP_507142.2  Glutathione S-transferase omega [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507142.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45352
    Conserved Domains (3) summary
    COG0625
    Location:29 → 229
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:8 → 98
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:112 → 245
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein
Heading Accession and Version

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