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aat-2 Amino Acid Transporter [ Caenorhabditis elegans ]

Gene ID: 184126, updated on 4-Jan-2025

Summary

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Official Symbol
aat-2
Official Full Name
Amino Acid Transporter
Primary source
WormBase:WBGene00000003
Locus tag
CELE_F07C3.7
See related
AllianceGenome:WB:WBGene00000003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See aat-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (9244402..9246360, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene X-linked retinitis pigmentosa GTPase regulator homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Seven TM Receptor Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. Caito SW, et al. Biochem Biophys Res Commun, 2013 Jun 14. PMID 23669041, Free PMC Article
  2. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Arantes LP, et al. Toxicol Res (Camb), 2016 Nov 1. PMID 28316775, Free PMC Article
  3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
  4. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Amino Acid Transporter
NP_505394.2
  • Product from WormBase gene class aat;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9244402..9246360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072993.6 → NP_505394.2  Amino Acid Transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505394.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19151
    Conserved Domains (1) summary
    TIGR00911
    Location:1 → 477
    2A0308; L-type amino acid transporter
Nucleotide Protein
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