aps-2 AP complex subunit sigma [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aps-2
Official Full Name: AP complex subunit sigma
Primary source: WormBase:WBGene00000157
Locus tag: CELE_F02E8.3
See related: AllianceGenome:WB:WBGene00000157
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin binding activity. Involved in several processes, including body morphogenesis; clathrin-dependent endocytosis; and nematode larval development. Predicted to be located in cell periphery; cytoplasm; and membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in neurons. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aps-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (4458272..4459255)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Levels of the GluR GLR-1 decreased at synapses in the ventral nerve cord (VNC) of Caenorhabditis elegans with mutations in the AP2 subunits APM-2/mu2, APA-2/alpha, or APS-2/sigma2
Title: The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F02E8.3 (e-PCR)
- UniSTS:316530

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AP complex subunit sigma

NP_508767.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4458272..4459255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076366.8 → NP_508767.1 AP complex subunit sigma [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508767.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19123

Conserved Domains (1) summary

cd14833
Location:1 → 141

AP2_sigma; AP-2 complex subunit sigma