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lipl-7 Lipase [ Caenorhabditis elegans ]

Gene ID: 184068, updated on 4-Jan-2025

Summary

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Official Symbol
lipl-7
Official Full Name
Lipase
Primary source
WormBase:WBGene00008510
Locus tag
CELE_F01G10.7
See related
AllianceGenome:WB:WBGene00008510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lipl-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10239278..10241823, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Enoyl-CoA Hydratase Neighboring gene ncRNA Neighboring gene Enoyl-CoA Hydratase Neighboring gene transketolase Neighboring gene BPI2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans. Huang WM, et al. Biochem J, 2014 Aug 1. PMID 24854345
  2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lipase
NP_501877.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10239278..10241823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069476.6 → NP_501877.2  Lipase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501877.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17766
    Conserved Domains (2) summary
    pfam00561
    Location:73 → 376
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:29 → 92
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
Nucleotide Protein
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