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mig-21 Abnormal cell migration protein 21 [ Caenorhabditis elegans ]

Gene ID: 184064, updated on 4-Jan-2025

Summary

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Official Symbol
mig-21
Official Full Name
Abnormal cell migration protein 21
Primary source
WormBase:WBGene00003252
Locus tag
CELE_F01F1.13
See related
AllianceGenome:WB:WBGene00003252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling receptor activity. Involved in several processes, including nervous system development; neuroblast migration; and regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Is expressed in QL; QR; and body wall musculature. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mig-21 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5876947..5878380, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein Neighboring gene MIF4G domain-containing protein Neighboring gene Fructose-bisphosphate aldolase 2 Neighboring gene ncRNA Neighboring gene COX assembly mitochondrial protein Neighboring gene SAC3/GANP/THP3 conserved domain-containing protein;SAC3_GANP domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans. Sundararajan L, et al. Genetics, 2012 Dec. PMID 23051647, Free PMC Article
  2. Genes regulating touch cell development in Caenorhabditis elegans. Du H, et al. Genetics, 2001 May. PMID 11333230, Free PMC Article
  3. The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration. Sundararajan L, et al. Dev Biol, 2014 Aug 15. PMID 24954154, Free PMC Article
  4. C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Buettner FF, et al. Mol Cell, 2013 Apr 25. PMID 23562325
  5. Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts. Ebbing A, et al. Development, 2019 Sep 25. PMID 31488562, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIG-21 and UNC-40 control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the two Q neuroblasts.
    Title: The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.
  2. an inherent left-right asymmetry in the Q neuroblasts with regard to UNC-40, PTP-3, and MIG-21 function that results in posterior vs. anterior migration of neuroblasts
    Title: Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of left/right asymmetry in nervous system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of left/right asymmetry in nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuroblast migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Abnormal cell migration protein 21
NP_001254933.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5876947..5878380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268004.4 → NP_001254933.2  Abnormal cell migration protein 21 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254933.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G1FC92, Q19092
    UniProtKB/TrEMBL
    M5FK96
    Conserved Domains (1) summary
    smart00209
    Location:65 → 105
    TSP1; Thrombospondin type 1 repeats
Nucleotide Protein
Heading Accession and Version

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