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E02H1.1 putative dimethyladenosine transferase [ Caenorhabditis elegans ]

Gene ID: 183993, updated on 9-Dec-2024

Summary

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Official Symbol
E02H1.1
Official Full Name
putative dimethyladenosine transferase
Primary source
WormBase:WBGene00008455
Locus tag
CELE_E02H1.1
See related
AllianceGenome:WB:WBGene00008455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity. Predicted to be involved in rRNA methylation and ribosomal small subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See E02H1.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (9589865..9591164, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative UDP-glucuronosyltransferase ugt-58 Neighboring gene GTPase Era, mitochondrial Neighboring gene putative tRNA pseudouridine synthase tag-124 Neighboring gene Poly [ADP-ribose] polymerase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear ribosome biogenesis mediated by the DIM1A rRNA dimethylase is required for organized root growth and epidermal patterning in Arabidopsis. Wieckowski Y, et al. Plant Cell, 2012 Jul. PMID 22829145, Free PMC Article
  2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
putative dimethyladenosine transferase
NP_496061.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9589865..9591164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063660.10 → NP_496061.2  putative dimethyladenosine transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496061.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09522
    Conserved Domains (1) summary
    PTZ00338
    Location:15 → 306
    PTZ00338; dimethyladenosine transferase-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09522.2

Gene LinkOut

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