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pde-3 Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3 [ Caenorhabditis elegans ]

Gene ID: 183981, updated on 9-Dec-2024

Summary

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Official Symbol
pde-3
Official Full Name
Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3
Primary source
WormBase:WBGene00008443
Locus tag
CELE_E01F3.1
See related
AllianceGenome:WB:WBGene00008443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including determination of adult lifespan; negative regulation of cGMP-mediated signaling; and response to hydrogen peroxide. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A) and PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pde-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (14919705..14953353)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox domain-containing protein Neighboring gene Cell wall protein DAN4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Elongation of very long chain fatty acids protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
  2. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article
  3. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article
  4. Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans. O'Halloran DM, et al. PLoS One, 2012. PMID 22319638, Free PMC Article
  5. Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans. Murayama T, et al. Curr Biol, 2013 Jun 3. PMID 23664973

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cGMP-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phototransduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to alkaline pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3
NP_001254452.1
  • Partially confirmed by transcript evidence
NP_001254454.1
  • Partially confirmed by transcript evidence
NP_001293569.1
  • Confirmed by transcript evidence
NP_001293570.1
  • Confirmed by transcript evidence
NP_001293571.1
  • Partially confirmed by transcript evidence
NP_001293572.1
  • Partially confirmed by transcript evidence
NP_001367248.1
  • Confirmed by transcript evidence
NP_001368261.1
  • Confirmed by transcript evidence
NP_001370153.1
  • Confirmed by transcript evidence
NP_497084.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14919705..14953353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383996.1 → NP_001370153.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam00233
    Location:302 → 557
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001306642.3 → NP_001293571.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEM9
    Conserved Domains (1) summary
    pfam00233
    Location:355 → 610
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_001381668.1 → NP_001367248.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FAS9, B7FAT0, G5EG24, Q8I0P7, Q9BH44
    Conserved Domains (1) summary
    pfam00233
    Location:355 → 610
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_001306643.3 → NP_001293572.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBF4
    Conserved Domains (1) summary
    pfam00233
    Location:302 → 557
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. NM_001306640.4 → NP_001293569.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PM84
    Conserved Domains (1) summary
    pfam00233
    Location:255 → 510
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. NM_001381670.1 → NP_001368261.1  Phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBS8
    Conserved Domains (1) summary
    pfam00233
    Location:255 → 510
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. NM_001267523.2 → NP_001254452.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I0P7
    Conserved Domains (1) summary
    pfam00233
    Location:251 → 506
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. NM_001306641.2 → NP_001293570.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRI1
    Conserved Domains (1) summary
    pfam00233
    Location:251 → 506
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  9. NM_064683.6 → NP_497084.2  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497084.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I0P7
    Conserved Domains (1) summary
    pfam00233
    Location:134 → 389
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  10. NM_001267525.3 → NP_001254454.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I0P7
    Conserved Domains (1) summary
    pfam00233
    Location:169 → 424
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I0P7.4

Gene LinkOut

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