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marc-2 RING-CH-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183961, updated on 4-Jan-2025

Summary

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Official Symbol
marc-2
Official Full Name
RING-CH-type domain-containing protein
Primary source
WormBase:WBGene00008433
Locus tag
CELE_D2089.2
See related
AllianceGenome:WB:WBGene00008433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in membrane. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1) and MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See marc-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (10660225..10660992, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Small nuclear ribonucleoprotein associated homolog 13 Neighboring gene ncRNA Neighboring gene putative splicing factor, arginine/serine-rich 7 Neighboring gene Cysteine-rich DPF motif domain-containing protein 1 Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis. Benavidez JM, et al. G3 (Bethesda), 2022 Apr 4. PMID 35134193, Free PMC Article
  2. trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans. Yuan L, et al. Elife, 2022 Aug 5. PMID 35929733, Free PMC Article
  3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-CH-type domain-containing protein
NP_496302.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10660225..10660992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063901.4 → NP_496302.2  RING-CH-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496302.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18997
    Conserved Domains (1) summary
    smart00744
    Location:24 → 72
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
Nucleotide Protein
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