che-1 C2H2-type domain-containing protein;Transcription factor che-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: che-1
Official Full Name: C2H2-type domain-containing protein;Transcription factor che-1
Primary source: WormBase:WBGene00000483
Locus tag: CELE_C55B7.12
See related: AllianceGenome:WB:WBGene00000483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including response to alkaline pH; response to lithium ion; and response to methionine. Predicted to be active in nucleus. Is expressed in ASEL and ASER. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See che-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (6517529..6520918, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of life-long maintenance of neuron identity despite molecular fluctuations.
Title: Mechanism of life-long maintenance of neuron identity despite molecular fluctuations.
che-1 autoregulation is indeed required to maintain the differentiated state of the ASE neurons but that it is also required to amplify che-1 expression during embryonic development to reach an apparent minimal threshold to initiate the ASE differentiation program.
Title: Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity.
through ectopic expression of single transcription factors (che-1) study found the identity of mitotic germ cells can be directly converted into that of specific neuron types; this reprogramming requires removal of LIN-53
Title: Direct conversion of C. elegans germ cells into specific neuron types.
Both lesions map to the cis-regulatory control region of cog-1 and affect a phylogenetically conserved binding site for the C2H2 zinc-finger transcription factor CHE-1.
Title: Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development.
The ASE motif is a binding site for the C2H2 zinc finger TF CHE-1, which is essential for the correct differentiation of the ASE gustatory neuron.
Title: The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron.
che-1 gene encodes a zinc finger transcription factor required for specification of the chemosensory neurons
Title: The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons.

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General gene information

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Markers

C55B7.12 (e-PCR)
- UniSTS:320256

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to alkaline pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lithium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to magnesium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to methionine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: C2H2-type domain-containing protein;Transcription factor che-1

NP_001076597.1

Confirmed by transcript evidence

NP_001076598.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6517529..6520918 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083129.2 → NP_001076598.1 C2H2-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076598.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0PCD8

Conserved Domains (3) summary

sd00017
Location:168 → 188

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:166 → 188

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:180 → 205

zf-H2C2_2; Zinc-finger double domain
NM_001083128.1 → NP_001076597.1 Transcription factor che-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q966L8

Conserved Domains (3) summary

sd00017
Location:109 → 129

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:107 → 129

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:121 → 146

zf-H2C2_2; Zinc-finger double domain