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nex-4 Annexin [ Caenorhabditis elegans ]

Gene ID: 183294, updated on 9-Dec-2024

Summary

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Official Symbol
nex-4
Official Full Name
Annexin
Primary source
WormBase:WBGene00003591
Locus tag
CELE_C37H5.1
See related
AllianceGenome:WB:WBGene00003591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in intestine and nervous system. Orthologous to human ANXA10 (annexin A10); ANXA8 (annexin A8); and ANXA9 (annexin A9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nex-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (4851472..4857276)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Abhydrolase domain-containing protein abhd-5.2 Neighboring gene Abhydrolase domain-containing protein abhd-5.1 Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein Neighboring gene Serpentine receptor class delta-32 Neighboring gene Serpentine receptor class delta-33 Neighboring gene Gamma-glutamyltranspeptidase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
  2. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
  3. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Annexin
NP_001309625.1
  • Confirmed by transcript evidence
NP_001368593.1
  • Confirmed by transcript evidence
NP_001379788.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4851472..4857276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322553.3 → NP_001309625.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB16
    Conserved Domains (1) summary
    pfam00191
    Location:305 → 370
    Annexin; Annexin

  2. NM_001380638.1 → NP_001368593.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBL3
    Conserved Domains (1) summary
    pfam00191
    Location:319 → 384
    Annexin

  3. NM_001392506.1 → NP_001379788.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91144
    Conserved Domains (1) summary
    pfam00191
    Location:266 → 331
    Annexin
Nucleotide Protein
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