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gcp-2.2 N-acetylated-alpha-linked acidic dipeptidase 2 [ Caenorhabditis elegans ]

Gene ID: 183230, updated on 9-Dec-2024

Summary

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Official Symbol
gcp-2.2
Official Full Name
N-acetylated-alpha-linked acidic dipeptidase 2
Primary source
WormBase:WBGene00007954
Locus tag
CELE_C35C5.2
See related
AllianceGenome:WB:WBGene00007954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carboxypeptidase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2); NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1); and FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcp-2.2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (11537714..11541538)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene Group-specific protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Thioredoxin reductase-like selenoprotein T homolog selt-1.1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uncovering the essential roles of glutamate carboxypeptidase 2 orthologs in Caenorhabditis elegans. Panska L, et al. Biosci Rep, 2024 Jan 31. PMID 38108122, Free PMC Article
  2. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylated-alpha-linked acidic dipeptidase 2
NP_509928.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11537714..11541538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077527.5 → NP_509928.3  N-acetylated-alpha-linked acidic dipeptidase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509928.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93332
    Conserved Domains (4) summary
    cd08022
    Location:372 → 614
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    cd02121
    Location:137 → 364
    PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
    pfam04253
    Location:652 → 773
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:75 → 133
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein
Heading Accession and Version

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