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mys-4 histone acetyltransferase [ Caenorhabditis elegans ]

Gene ID: 183194, updated on 4-Jan-2025

Summary

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Official Symbol
mys-4
Official Full Name
histone acetyltransferase
Primary source
WormBase:WBGene00007914
Locus tag
CELE_C34B7.4
See related
AllianceGenome:WB:WBGene00007914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of histone H3-K14 acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mys-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (8333082..8336727)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein uL23B Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene SAC domain-containing protein Neighboring gene putative cytochrome P450 CYP36A1 Neighboring gene Tubulin alpha chain Neighboring gene Tudor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Shibata Y, et al. Development, 2010 Apr. PMID 20181741
  2. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol CJ, et al. Dev Cell, 2004 Apr. PMID 15068795
  3. Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. Cui M, et al. PLoS Genet, 2006 May. PMID 16710447, Free PMC Article
  4. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905
  5. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone H3-K14 acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone acetyltransferase
NP_492265.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8333082..8336727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059864.4 → NP_492265.1  histone acetyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492265.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZX6
    Conserved Domains (4) summary
    PLN00058
    Location:35 → 117
    PLN00058; photosystem II reaction center subunit T; Provisional
    smart00249
    Location:147 → 193
    PHD; PHD zinc finger
    pfam01853
    Location:391 → 565
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:347 → 603
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
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