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mps-1 MiRP K channel accessory Subunit [ Caenorhabditis elegans ]

Gene ID: 183012, updated on 4-Jan-2025

Summary

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Official Symbol
mps-1
Official Full Name
MiRP K channel accessory Subunit
Primary source
WormBase:WBGene00003403
Locus tag
CELE_C29F5.4
See related
AllianceGenome:WB:WBGene00003403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables potassium channel regulator activity and protein serine/threonine kinase activity. Involved in several processes, including hyperosmotic response; mechanosensory behavior; and negative regulation of potassium ion transport. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in sensory neurons and vulva. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mps-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (6292452..6294361, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DUF4238 domain-containing protein Neighboring gene CN hydrolase domain-containing protein Neighboring gene RNase NYN domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution NMR of MPS-1 reveals a random coil cytosolic domain structure. Li P, et al. PLoS One, 2014. PMID 25347290, Free PMC Article
  2. Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning. Cai SQ, et al. EMBO J, 2009 Jun 3. PMID 19387491, Free PMC Article
  3. MPS-1 is a K+ channel beta-subunit and a serine/threonine kinase. Cai SQ, et al. Nat Neurosci, 2005 Nov. PMID 16222231
  4. A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans. Bianchi L, et al. J Biol Chem, 2003 Apr 4. PMID 12533541
  5. An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels. Cotella D, et al. FASEB J, 2013 Apr. PMID 23233530, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic, biochemical and electrophysiological evidence show that KHT-1 and MPS-1 form a complex in vitro and in native mechanosensory PLM neurons, and that KHT-1 is a substrate for the kinase activity of MPS-1.
    Title: Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning.
  2. The transmembrane domain of MPS-1 is necessary and sufficient for MPS-1 complex formation; a hydropathic mechanism may allow MPS-1 to assemble with various voltage-gated potassium Kv channels, presumably modifying the electrical properties of each.
    Title: Molecular mechanisms underlying KVS-1-MPS-1 complex assembly.
  3. three different MPS subunits combine with KVS-1 to form both binary (MPS-1.KVS-1) and ternary (MPS-2.MPS-3.KVS-1) complexes in chemosensory neurons
    Title: A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans.
  4. This study report the K+ channel beta-subunit that is also a serine/threonine kinase. MPS-1 is a single-transmembrane domain protein that coassembles with voltage-gated K+ channel KVS-1 in the nervous system of the Caenorhabditis elegans.
    Title: MPS-1 is a K+ channel beta-subunit and a serine/threonine kinase.
  5. the cloning and functional characterization of a MiRP beta-subunit, MPS-1, and of a voltage-gated pore-forming potassium subunit, KVS-1 [MPS-1] [KVS-1]
    Title: A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MiRP K channel accessory Subunit
NP_495263.2
  • Product from WormBase gene class mps;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6292452..6294361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062862.5 → NP_495263.2  MiRP K channel accessory Subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495263.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27GU3, Q86GJ0
Nucleotide Protein
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