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ascc-1 K Homology domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182817, updated on 4-Jan-2025

Summary

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Official Symbol
ascc-1
Official Full Name
K Homology domain-containing protein
Primary source
WormBase:WBGene00016019
Locus tag
CELE_C23H3.3
See related
AllianceGenome:WB:WBGene00016019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ascc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (57670..60040)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nucleolus and neural progenitor protein-like N-terminal domain-containing protein Neighboring gene Serine palmitoyltransferase 1 Neighboring gene Trehalase Neighboring gene DUF3810 domain-containing protein Neighboring gene Egg-laying defective protein 26

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
K Homology domain-containing protein
NP_001122591.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    57670..60040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129119.3 → NP_001122591.1  K Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9Z1L6
    Conserved Domains (2) summary
    smart00322
    Location:99 → 164
    KH; K homology RNA-binding domain
    pfam10469
    Location:177 → 392
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. NR_132568.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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