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hlh-27 BHLH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182719, updated on 2-Nov-2024

Summary

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Official Symbol
hlh-27
Official Full Name
BHLH domain-containing protein
Primary source
WormBase:WBGene00001966
Locus tag
CELE_C17C3.10
See related
AllianceGenome:WB:WBGene00001966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ABpla; ABplp; ABpra; ABprp; and MS. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-27 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (5539075..5540213, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Helix-loop-helix protein 26 Neighboring gene Helix-loop-helix protein 25 Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Methot SP, et al. Nat Cell Biol, 2021 Nov. PMID 34737442, Free PMC Article
  2. The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. Neves A, et al. Dev Cell, 2005 Jun. PMID 15935776
  3. Notch signaling in the C. elegans embryo. Priess JR. WormBook, 2005 Jun 25. PMID 18050407, Free PMC Article
  4. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Grove CA, et al. Cell, 2009 Jul 23. PMID 19632181, Free PMC Article
  5. The C. elegans pharynx: a model for organogenesis. Mango SE. WormBook, 2007 Jan 22. PMID 18050503, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BHLH domain-containing protein
NP_495065.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5539075..5540213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062664.4 → NP_495065.2  BHLH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495065.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18056
    Conserved Domains (1) summary
    pfam00010
    Location:94 → 148
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
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