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hlh-25 Helix-loop-helix protein 25 [ Caenorhabditis elegans ]

Gene ID: 182717, updated on 2-Nov-2024

Summary

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Official Symbol
hlh-25
Official Full Name
Helix-loop-helix protein 25
Primary source
WormBase:WBGene00001964
Locus tag
CELE_C17C3.7
See related
AllianceGenome:WB:WBGene00001964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ABpla; ABplp; PDE; anal depressor muscle; and body wall musculature. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-25 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (5535239..5536405)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein Neighboring gene Helix-loop-helix protein 26 Neighboring gene Protein kinase domain-containing protein Neighboring gene BHLH domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HES-Mediated Repression of Pten in Caenorhabditis elegans. Chou HT, et al. G3 (Bethesda), 2015 Oct 4. PMID 26438299, Free PMC Article
  2. H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Methot SP, et al. Nat Cell Biol, 2021 Nov. PMID 34737442, Free PMC Article
  3. The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. Neves A, et al. Dev Cell, 2005 Jun. PMID 15935776
  4. Notch signaling in the C. elegans embryo. Priess JR. WormBook, 2005 Jun 25. PMID 18050407, Free PMC Article
  5. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Grove CA, et al. Cell, 2009 Jul 23. PMID 19632181, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer exit IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Helix-loop-helix protein 25
NP_495063.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5535239..5536405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062662.3 → NP_495063.2  Helix-loop-helix protein 25 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495063.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18054
    Conserved Domains (1) summary
    pfam00010
    Location:94 → 148
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
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