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sox-4 HMG box domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182547, updated on 9-Dec-2024

Summary

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Official Symbol
sox-4
Official Full Name
HMG box domain-containing protein
Primary source
WormBase:WBGene00015716
Locus tag
CELE_C12D12.5
See related
AllianceGenome:WB:WBGene00015716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in innate immune response. Predicted to be active in nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome (multiple); gonadal dysgenesis (multiple); hypotrichosis-lymphedema-telangiectasia syndrome; hypotrichosis-lymphedema-telangiectasia-renal defect syndrome; and urinary bladder cancer. Orthologous to several human genes including SOX11 (SRY-box transcription factor 11); SOX12 (SRY-box transcription factor 12); and SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sox-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (3505270..3509006, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Excitatory amino acid transporter Neighboring gene IgGFc_binding domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo. Kagias K, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493276, Free PMC Article
  2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response HEP PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HMG box domain-containing protein
NP_001335567.1
  • Confirmed by transcript evidence
NP_001379663.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3505270..3509006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392746.1 → NP_001379663.1  HMG box domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17922
    Conserved Domains (1) summary
    cd01388
    Location:84 → 155
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  2. NM_001348598.3 → NP_001335567.1  HMG box domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SZG1
    Conserved Domains (1) summary
    cd01388
    Location:120 → 191
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
Nucleotide Protein
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Gene LinkOut

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