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tsg-101 Tumor susceptibility gene 101 protein [ Caenorhabditis elegans ]

Gene ID: 182474, updated on 2-Nov-2024

Summary

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Official Symbol
tsg-101
Official Full Name
Tumor susceptibility gene 101 protein
Primary source
WormBase:WBGene00015658
Locus tag
CELE_C09G12.9
See related
AllianceGenome:WB:WBGene00015658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin binding activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in endosome membrane. Part of ESCRT I complex. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tsg-101 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (3509631..3514567, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene Ras-related protein ced-10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Amidohydrolase-related domain-containing protein;Protein unc-33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peripubertal requirement of Tsg101 in maintaining the integrity of membranous structures in mouse oocytes. Shin H, et al. Cell Prolif, 2022 Oct. PMID 35768997, Free PMC Article
  2. The ESCRT-III protein CeVPS-32 is enriched in domains distinct from CeVPS-27 and CeVPS-23 at the endosomal membrane of epithelial cells. Michelet X, et al. Biol Cell, 2009 Jul 31. PMID 19432559
  3. MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. Audhya A, et al. PLoS One, 2007 Sep 26. PMID 17895996, Free PMC Article
  4. Loss of the Major Phosphatidylserine or Phosphatidylethanolamine Flippases Differentially Affect Phagocytosis. Fazeli G, et al. Front Cell Dev Biol, 2020. PMID 32793595, Free PMC Article
  5. Differential physiological roles of ESCRT complexes in Caenorhabditis elegans. Kim DW, et al. Mol Cells, 2011 Jun. PMID 21688204, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome to lysosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tumor susceptibility gene 101 protein
NP_500364.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3509631..3514567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067963.6 → NP_500364.2  Tumor susceptibility gene 101 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500364.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76258
    Conserved Domains (2) summary
    pfam05743
    Location:21 → 139
    UEV; UEV domain
    pfam09454
    Location:353 → 408
    Vps23_core; Vps23 core domain
Nucleotide Protein
Heading Accession and Version

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