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ctsa-3.2 Serine carboxypeptidase ctsa-3.2 [ Caenorhabditis elegans ]

Gene ID: 182429, updated on 9-Dec-2024

Summary

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Official Symbol
ctsa-3.2
Official Full Name
Serine carboxypeptidase ctsa-3.2
Primary source
WormBase:WBGene00007462
Locus tag
CELE_C08H9.1
See related
AllianceGenome:WB:WBGene00007462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ctsa-3.2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (9875179..9877887)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene GH18 domain-containing protein Neighboring gene GH18 domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation. Zhang Q, et al. J Cell Biol, 2023 Jun 5. PMID 37058288, Free PMC Article
  2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine carboxypeptidase ctsa-3.2
NP_001364589.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9875179..9877887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377839.2 → NP_001364589.1  Serine carboxypeptidase ctsa-3.2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52714
    Conserved Domains (1) summary
    pfam00450
    Location:27 → 505
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52714.2

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