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ckk-1 Calcium/calmodulin-dependent protein kinase kinase [ Caenorhabditis elegans ]

Gene ID: 182278, updated on 2-Nov-2024

Summary

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Official Symbol
ckk-1
Official Full Name
Calcium/calmodulin-dependent protein kinase kinase
Primary source
WormBase:WBGene00000518
Locus tag
CELE_C05H8.1
See related
AllianceGenome:WB:WBGene00000518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in CAMKK-AMPK signaling cascade. Located in cytoplasm and nucleus. Is expressed in head neurons; tail neurons; and vulval muscle. Orthologous to several human genes including CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ckk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (5635479..5654564)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation. Eto K, et al. J Biol Chem, 1999 Aug 6. PMID 10428833
  2. Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor. Ippolito D, et al. Elife, 2023 May 11. PMID 37166173, Free PMC Article
  3. 5'-AMP-activated protein kinase signaling in Caenorhabditis elegans. Beale EG. Exp Biol Med (Maywood), 2008 Jan. PMID 18156301
  4. Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain. Tokumitsu H, et al. J Biol Chem, 1999 May 28. PMID 10336483
  5. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. Kimura Y, et al. EMBO Rep, 2002 Oct. PMID 12231504, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calcium/calmodulin-dependent protein kinase kinase
NP_001021152.1
  • Confirmed by transcript evidence
NP_001021153.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5635479..5654564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025982.5 → NP_001021153.1  Calcium/calmodulin-dependent protein kinase kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021153.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4RS26, G5EDZ4, Q3Y416
    Conserved Domains (2) summary
    smart00220
    Location:130 → 411
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14118
    Location:135 → 412
    STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase

  2. NM_001025981.3 → NP_001021152.1  Calcium/calmodulin-dependent protein kinase kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3Y416
    Conserved Domains (2) summary
    smart00220
    Location:21 → 302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14118
    Location:26 → 303
    STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3Y416.2

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