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scrm-3 Phospholipid scramblase [ Caenorhabditis elegans ]

Gene ID: 182212, updated on 4-Jan-2025

Summary

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Official Symbol
scrm-3
Official Full Name
Phospholipid scramblase
Primary source
WormBase:WBGene00015437
Locus tag
CELE_C04E12.7
See related
AllianceGenome:WB:WBGene00015437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; body wall musculature; and nervous system. Orthologous to several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See scrm-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (3355848..3357206, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene pseudo Neighboring gene PAW domain-containing protein Neighboring gene PAW domain-containing protein Neighboring gene DUF19 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Venegas V, et al. Mol Biol Cell, 2007 Aug. PMID 17567952, Free PMC Article
  2. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785
  3. Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system. Von Stetina SE, et al. Genome Biol, 2007. PMID 17612406, Free PMC Article
  4. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Wang X, et al. Nat Cell Biol, 2007 May. PMID 17401362
  5. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid scramblase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phospholipid scramblase
NP_503934.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3355848..3357206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071533.4 → NP_503934.2  Phospholipid scramblase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503934.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG07
    Conserved Domains (1) summary
    cl02043
    Location:41 → 249
    LOR; LURP-one-related
Nucleotide Protein
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