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C03H5.4 Phospholipase A2 [ Caenorhabditis elegans ]

Gene ID: 182181, updated on 4-Jan-2025

Summary

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Official Symbol
C03H5.4
Official Full Name
Phospholipase A2
Primary source
WormBase:WBGene00015406
Locus tag
CELE_C03H5.4
See related
AllianceGenome:WB:WBGene00015406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; familial benign fleck retina; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to human PLA2G2A (phospholipase A2 group IIA); PLA2G2E (phospholipase A2 group IIE); and PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See C03H5.4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (375250..375835)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T Neighboring gene Seven TM Receptor Neighboring gene TPR_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phospholipase A2
NP_493719.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    375250..375835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061318.3 → NP_493719.3  Phospholipase A2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16654
    Conserved Domains (1) summary
    cd00125
    Location:20 → 134
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RNA

  1. NR_132577.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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