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scpl-1 CTD small phosphatase-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 181944, updated on 9-Dec-2024

Summary

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Official Symbol
scpl-1
Official Full Name
CTD small phosphatase-like protein 1
Primary source
WormBase:WBGene00007054
Locus tag
CELE_B0379.4
See related
AllianceGenome:WB:WBGene00007054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Orthologous to several human genes including CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See scpl-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (10086265..10102012, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene MUTator Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle. Xiong G, et al. J Mol Biol, 2009 Mar 6. PMID 19244614, Free PMC Article
  2. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article
  3. ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration. Lecroisey C, et al. Mol Biol Cell, 2013 Apr. PMID 23427270, Free PMC Article
  4. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
  5. CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Warner A, et al. Mol Biol Cell, 2013 Mar. PMID 23283987, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCPL-1 interacts with LIM-9 (FHL), a protein that we first discovered as an interactor of UNC-97 (PINCH) and UNC-96, components of an M-line costamere in nematode muscle.
    Title: A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
  2. Yeast two-hybrid screening using a portion of UNC-89 including PK2, yielded SCPL-1 (small CTD phosphatase-like-1), which contains a C terminal domain (CTD) phosphatase type domain.
    Title: A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables LIM domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD small phosphatase-like protein 1
NP_001122411.1
  • Confirmed by transcript evidence
NP_001370133.1
  • Confirmed by transcript evidence
NP_740912.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10086265..10102012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128939.3 → NP_001122411.1  CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122411.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T3G2
    Conserved Domains (2) summary
    COG5190
    Location:66 → 224
    FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
    TIGR02251
    Location:70 → 224
    HIF-SF_euk; Dullard-like phosphatase domain

  2. NM_001383711.2 → NP_001370133.1  CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    TIGR02251
    Location:165 → 319
    HIF-SF_euk; Dullard-like phosphatase domain

  3. NM_170918.7 → NP_740912.2  CTD small phosphatase-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740912.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5Z2W8, Q8T3G2, Q8T3G3
    Conserved Domains (1) summary
    TIGR02251
    Location:311 → 465
    HIF-SF_euk; Dullard-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3G2.2

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