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npr-41 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181927, updated on 4-Jan-2025

Summary

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Official Symbol
npr-41
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00007146
Locus tag
CELE_B0334.6
See related
AllianceGenome:WB:WBGene00007146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including GPR142 (G protein-coupled receptor 142). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See npr-41 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (11510673..11513892)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene Major sperm protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic behavioral screen identifies an orphan anti-opioid system. Wang D, et al. Science, 2019 Sep 20. PMID 31416932, Free PMC Article
  2. The neuropeptidergic connectome of C. elegans. Ripoll-Sánchez L, et al. Neuron, 2023 Nov 15. PMID 37935195, Free PMC Article
  3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_496459.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11510673..11513892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064058.7 → NP_496459.2  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496459.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17478
    Conserved Domains (1) summary
    cd14978
    Location:43 → 348
    7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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