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nas-6 Metalloendopeptidase;Zinc metalloproteinase nas-6 [ Caenorhabditis elegans ]

Gene ID: 181796, updated on 9-Dec-2024

Summary

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Official Symbol
nas-6
Official Full Name
Metalloendopeptidase;Zinc metalloproteinase nas-6
Primary source
WormBase:WBGene00003525
Locus tag
CELE_4R79.1
See related
AllianceGenome:WB:WBGene00003525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Involved in nematode pharyngeal pumping and pharynx development. Predicted to be located in extracellular region. Is expressed in body wall musculature; hyp7 syncytium; intestine; mc2; and pharyngeal muscle cell. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nas-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (17486842..17490779, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Putative glucosylceramidase 3 Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-44 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode. Ishita Y, et al. Mol Biol Evol, 2023 Dec 1. PMID 38105444, Free PMC Article
  2. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
  3. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  4. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
  5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Metalloendopeptidase;Zinc metalloproteinase nas-6
NP_001040902.1
  • Confirmed by transcript evidence
NP_001040903.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17486842..17490779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047437.2 → NP_001040902.1  Zinc metalloproteinase nas-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7Z0N6, Q9U3S9
    Conserved Domains (3) summary
    cd04280
    Location:83 → 263
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:80 → 265
    Astacin; Astacin (Peptidase family M12A)
    pfam01549
    Location:299 → 334
    ShK; ShK domain-like

  2. NM_001047438.2 → NP_001040903.1  Metalloendopeptidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2HQL9
    Conserved Domains (2) summary
    pfam01549
    Location:135 → 170
    ShK; ShK domain-like
    cl00064
    Location:1 → 99
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RNA

  1. NR_132470.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3S9.2

Gene LinkOut

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