mec-4 Degenerin mec-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-4
Official Full Name: Degenerin mec-4
Primary source: WormBase:WBGene00003168
Locus tag: CELE_T01C8.7
See related: AllianceGenome:WB:WBGene00003168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ligand-gated sodium channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; negative regulation of turning behavior involved in mating; and positive regulation of detection of mechanical stimulus involved in sensory perception of touch. Located in axon and neuron projection membrane. Is expressed in touch receptor neurons. Used to study ischemia and neurodegenerative disease. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 2; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to several human genes including SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mec-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (16803321..16807115, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans.
Title: Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans.
Progressive recruitment of distal MEC-4 channels determines touch response strength in C. elegans.
Title: Progressive recruitment of distal MEC-4 channels determines touch response strength in C. elegans.
we found that the worm's response to ultrasound pulses rests on the expression of MEC-4, a DEG/ENaC/ASIC ion channel required for touch sensation
Title: Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System.
Here we demonstrate that diapause promotes the complete morphological regeneration of truncated touch receptor neuron (TRN) axons expressing a neurotoxic MEC-4(d) DEG/ENaC channel
Title: Diapause induces functional axonal regeneration after necrotic insult in C. elegans.
MEC-6 and POML-1 interact with MEC-4 to facilitate expression and localization of MEC-4 on the cell surface. Thus MEC-6 and POML-1 act more like chaperones for MEC-4 than channel components.
Title: Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.
MEC-10, but not MEC-6, forms puncta in touch receptor neurites that colocalize with MEC-4 when MEC-4 is overexpressed in the touch receptor neurons
Title: Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.
Ubiquitination of MEC-4 reduces the amount of MEC-4 protein in the processes of ALM neurons and, consequently, the mechanoreceptor current.
Title: Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel.
MEC-4/MEC-10 DEG/ENaC or its partners MEC-6, MEC-7, and MEC-9 blocked DAF-16::GFP nuclear accumulation induced by hypergravity but did not affect DAF-16 response to other stresses
Title: Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.
MEC-4 is distributed essentially evenly with MEC-2 around the circumference of touch receptor neurites that serve as gating tethers critical for channel activation by mechano-electrical transduction.
Title: Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons.
The d position is part of a key region in the channel functionally and structurally, possibly representing the beginning of a pore-forming domain.
Title: Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01C8.7 (e-PCR)
- UniSTS:310596

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of turning behavior involved in mating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Degenerin mec-4

NP_510712.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16803321..16807115 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078311.8 → NP_510712.2 Degenerin mec-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510712.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P24612

Conserved Domains (3) summary

TIGR00867
Location:86 → 736

deg-1; degenerin

pfam00858
Location:87 → 172

ASC; Amiloride-sensitive sodium channel

cl02990
Location:428 → 739

ASC; Amiloride-sensitive sodium channel