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sur-7 SUppressor of activated let-60 Ras [ Caenorhabditis elegans ]

Gene ID: 181707, updated on 9-Dec-2024

Summary

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Official Symbol
sur-7
Official Full Name
SUppressor of activated let-60 Ras
Primary source
WormBase:WBGene00006353
Locus tag
CELE_F01G12.2
See related
AllianceGenome:WB:WBGene00006353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Is expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sur-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (16376595..16380050)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acetylcholinesterase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Collagen alpha-2(IV) chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans. Sharma AK, et al. Front Physiol, 2023. PMID 37822680, Free PMC Article
  2. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Zhang JJ, et al. J Lipid Res, 2017 Sep. PMID 28710073, Free PMC Article
  3. Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids. Casorla-Perez LA, et al. J Virol, 2022 Nov 23. PMID 36342299, Free PMC Article
  4. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. Murphy JT, et al. PLoS Genet, 2011 Mar. PMID 21455490, Free PMC Article
  5. Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation. Fisher K, et al. Biol Open, 2013 Dec 15. PMID 24285704, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cellular response to zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein stability IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUppressor of activated let-60 Ras
NP_001379862.1
  • Product from WormBase gene class sur;
    Confirmed by transcript evidence
NP_741942.1
  • Product from WormBase gene class sur;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16376595..16380050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392907.1 → NP_001379862.1  SUppressor of activated let-60 Ras [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZM3

  2. NM_171809.4 → NP_741942.1  SUppressor of activated let-60 Ras [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19096

RNA

  1. NR_132551.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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