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nhr-28 Nuclear hormone receptor family member nhr-28 [ Caenorhabditis elegans ]

Gene ID: 181705, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-28
Official Full Name
Nuclear hormone receptor family member nhr-28
Primary source
WormBase:WBGene00003624
Locus tag
CELE_C11G6.4
See related
AllianceGenome:WB:WBGene00003624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in body wall; head; hypodermis; intestine; and pharynx. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-28 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (16354976..16359650)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
  2. Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. Robinson-Rechavi M, et al. J Mol Evol, 2005 May. PMID 15983867
  3. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Arda HE, et al. Mol Syst Biol, 2010 May 11. PMID 20461074, Free PMC Article
  4. An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. Vergani-Junior CA, et al. Nat Commun, 2024 Apr 9. PMID 38594249, Free PMC Article
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-28
NP_001024388.1
  • Confirmed by transcript evidence
NP_001024389.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16354976..16359650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029217.7 → NP_001024388.1  Nuclear hormone receptor family member nhr-28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024388.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17905, Q17906, Q5FC68, Q5VKU0, Q9GTI2, Q9GTI3
    Conserved Domains (2) summary
    smart00399
    Location:7 → 76
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:168 → 345
    HOLI; Ligand binding domain of hormone receptors

  2. NM_001029218.7 → NP_001024389.1  Nuclear hormone receptor family member nhr-28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024389.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17905
    Conserved Domains (2) summary
    smart00430
    Location:110 → 287
    HOLI; Ligand binding domain of hormone receptors
    cl02596
    Location:2 → 25
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17905.3

Gene LinkOut

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