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nkat-3 kynurenine--oxoglutarate transaminase [ Caenorhabditis elegans ]

Gene ID: 181633, updated on 4-Jan-2025

Summary

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Official Symbol
nkat-3
Official Full Name
kynurenine--oxoglutarate transaminase
Primary source
WormBase:WBGene00010984
Locus tag
CELE_R03A10.4
See related
AllianceGenome:WB:WBGene00010984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kynurenine-oxoglutarate transaminase activity. Predicted to be involved in L-kynurenine metabolic process and biosynthetic process. Predicted to be active in mitochondrion. Is expressed in gonad; neurons; pharyngeal muscle cell; and tail. Orthologous to several human genes including KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nkat-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (15441731..15443630)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene Molybdenum cofactor sulfurase Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
  2. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Bender LB, et al. Development, 2006 Oct. PMID 16968818, Free PMC Article
  3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine--oxoglutarate transaminase
NP_001024822.1
  • Confirmed by transcript evidence
NP_001024823.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15441731..15443630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029651.6 → NP_001024822.1  kynurenine--oxoglutarate transaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MP09
    Conserved Domains (1) summary
    PRK08912
    Location:44 → 435
    PRK08912; aminotransferase

  2. NM_001029652.7 → NP_001024823.1  kynurenine--oxoglutarate transaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5FC69
    Conserved Domains (1) summary
    PRK08912
    Location:27 → 418
    PRK08912; aminotransferase
Nucleotide Protein
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