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nfki-1 ANK repeat-containing protein nipk-1 [ Caenorhabditis elegans ]

Gene ID: 181625, updated on 4-Jan-2025

Summary

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Official Symbol
nfki-1
Official Full Name
ANK repeat-containing protein nipk-1
Primary source
WormBase:WBGene00007877
Locus tag
CELE_C33A11.1
See related
AllianceGenome:WB:WBGene00007877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in positive regulation of cell differentiation and regulation of transcription by RNA polymerase II. Is expressed in several structures, including nervous system. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nfki-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (15355238..15363861)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Aa_trans domain-containing protein Neighboring gene tRNA Neighboring gene ETS domain-containing protein;Ets-domain protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. Brena D, et al. Sci Rep, 2020 Sep 30. PMID 32999373, Free PMC Article
  2. IL-17: good fear no tears. Rua R, et al. Nat Immunol, 2020 Nov. PMID 32958929
  3. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Chen C, et al. Nature, 2017 Feb 2. PMID 28099418, Free PMC Article
  4. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
  5. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ANK repeat-containing protein nipk-1
NP_510540.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15355238..15363861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078139.5 → NP_510540.1  ANK repeat-containing protein nipk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510540.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDE9
    Conserved Domains (3) summary
    cd00204
    Location:412 → 552
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:375 → 415
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:372 → 447
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EDE9.1

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