seb-3 G_PROTEIN_RECEP_F2_4 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: seb-3
Official Full Name: G_PROTEIN_RECEP_F2_4 domain-containing protein
Primary source: WormBase:WBGene00007664
Locus tag: CELE_C18B12.2
See related: AllianceGenome:WB:WBGene00007664
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled peptide receptor activity. Involved in behavioral response to ethanol; locomotory behavior; and response to heat. Located in axon and neuronal cell body. Is expressed in body wall musculature; nervous system; ray 1; and rectal gland cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in achalasia; cardiovascular system disease; diabetes mellitus; isolated growth hormone deficiency (multiple); and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); ADGRF3 (adhesion G protein-coupled receptor F3); and GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See seb-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (15026308..15031202)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptidergic regulation of compulsive ethanol seeking in C. elegans.
Title: Neuropeptidergic regulation of compulsive ethanol seeking in C. elegans.
High-content analysis of locomotor behaviour indicates that seb-3 and nlp-49 deletion mutants cause remarkably similar abnormalities in movement dynamics, which are reversed by overexpression of wild-type transgenes. Overexpression of NLP-49 in AVK interneurons leads to heightened locomotor arousal, an effect that is dependent on seb-3.
Title: Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3.
SEB-3 expressed in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans.
Title: CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans.
Characterization of a loss-of-function allele of seb-3 that showed that SEB-3 positively regulates a stress response that leads to an enhanced active state of locomotion, behavioral arousal and tremor.
Title: SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18B12B.1 (e-PCR)
- UniSTS:313713

C18B12.2 (e-PCR)
- UniSTS:317888

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axolemma	IC Inferred by Curator more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G_PROTEIN_RECEP_F2_4 domain-containing protein

NP_510496.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15026308..15031202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078095.7 → NP_510496.1 G_PROTEIN_RECEP_F2_4 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510496.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBF7

Conserved Domains (2) summary

pfam02793
Location:27 → 90

HRM; Hormone receptor domain

cl21561
Location:125 → 367

7tm_4; Olfactory receptor