rbg-1 Rab3 GTPase-activating protein catalytic subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rbg-1
Official Full Name: Rab3 GTPase-activating protein catalytic subunit
Primary source: WormBase:WBGene00004317
Locus tag: CELE_F20D1.6
See related: AllianceGenome:WB:WBGene00004317
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in amyloid fibril formation; autophagy; and positive regulation of autophagosome assembly. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rbg-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (14983533..14987365)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20D1.6 (e-PCR)
- UniSTS:307511

F20D1.4 (e-PCR)
- UniSTS:316587

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rab3 GTPase-activating protein catalytic subunit

NP_510490.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14983533..14987365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078089.6 → NP_510490.1 Rab3 GTPase-activating protein catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510490.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93538

Conserved Domains (1) summary

pfam13890
Location:572 → 704

Rab3-GTPase_cat; Rab3 GTPase-activating protein catalytic subunit