mrp-5 Multidrug resistance-associated protein 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrp-5
Official Full Name: Multidrug resistance-associated protein 5
Primary source: WormBase:WBGene00003411
Locus tag: CELE_F14F4.3
See related: AllianceGenome:WB:WBGene00003411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ABC-type vitamin B12 transporter activity. Involved in cobalamin transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including body wall musculature; hypodermis; intestine; muscle cell; and pharynx. Orthologous to several human genes including ABCC12 (ATP binding cassette subfamily C member 12) and ABCC5 (ATP binding cassette subfamily C member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mrp-5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 20

Sequence:: Chromosome: X; NC_003284.9 (14938502..14946317, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a multidrug resistance protein MRP-5/ABCC5 likely acts as a cellular heme exporter and is essential for viability in Caenorhabditis elegans.
Title: Control of metazoan heme homeostasis by a conserved multidrug resistance protein.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F14F4.3 (e-PCR)
- UniSTS:309749

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type vitamin B12 transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cobalamin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IC Inferred by Curator more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Multidrug resistance-associated protein 5

NP_510479.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14938502..14946317 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078078.4 → NP_510479.1 Multidrug resistance-associated protein 5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510479.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EE72

Conserved Domains (1) summary

TIGR00957
Location:90 → 1340

MRP_assoc_pro; multi drug resistance-associated protein (MRP)